Conferenceseries Llc Ltd cordially invites you to attend the “16th World Congress on Advances in Stem Cell Research and Regenerative Medicine”, on which is forthcoming in the month of November 21-22, 2022 at Montreal, Canada.

Theme: "Recent Developments and New Innovations in the field of Stem Cell and Regenerative Medicine"

Generation and Maintenance of Stem Cells:

Cell divisions during embryonic development give rise to new differentiated cell types or increase the total number of cells in the embryo. In contrast, the major role of cell division in adult life is to maintain the number of differentiated cells at a constant level: to replace cells that have died or been lost through injury.

• Stem cells
• Differentiation
• Growth factors
• Extracellular matrix
• Stem cell heterogeneity
• Epidermis
• Haemopoiesis
• Gastrointestinal epithelium

Tissue Engineering:

Many more deaths occurred thanks to less availability of organs and donors. Tissue engineering/ Regenerative medicine opens the trail to make and generate desired tissue, cells also as Organs in Vitro to fight against the limitation and to make a replacement hope within the field of transplantation to fill the damaged and missing body parts. While rehabilitation engineering helps to revive normal function. Spanning use of cell, pharmacological and bioengineering technologies, alongside physical modalities and exercise.

• Whole organ engineering
• Extracellular matrix analog
• Auricular cartilage reconstruction
• Biomaterials and biopolymers for tissue engineering
• Hydrogels for tissue engineering
• Dermal tissue and Stem cell engineering

Stem Cell Microenvironment:

Stem cell microenvironment is the general term of the three-dimensional structure and a variety of signaling molecules (growth factors and their receptors, hormones and signaling molecules) present in the stroma where the stem cells reside and it can regulate the fate (proliferation/differentiation) of the stem cells.

• Repair of the stem cell microenvironment
• Autologous cells
• Stem cells in ocular tissues
• Biomaterials and biopolymers for tissue engineering
• Stem cell therapy for corneal diseases
• Stem cell treatment for retinitis pigmentosa

Systems analysis of stem cells:

Stem-cell research is the area of research that studies the properties of stem cells and their potential use in medicine. As stem cells are the source of all tissues, understanding their properties helps in our understanding of the healthy and diseased body's development and homeostasis.

• Transient clone
• Stem cell clone
• Lineage tracing methods
• Identifying stem cells
• Stem cell replacement
• Analyzing stem cells
• Follicle cell transient clone development
• Follicle stem cell clone

Stem cell ageing:

The stem cell theory of aging postulates that the aging process is the result of the inability of various types of stem cells to continue to replenish the tissues of an organism with functional differentiated cells capable of maintaining that tissue's (or organ's) original function.

• Toxic metabolites in stem cells
• DNA damage in aging stem cells
• Restore stem cell function
• Protein homeostasis
• Reversing stem cell aging
• Mitochondrial dysfunction

COVID-19 and Convalescent Plasma:

The use of convalescent plasma (CP) collected from previously infected individuals to passively transfer antibodies so as to guard or treat humans dates back almost 100 years. Results from small case series during the prior MERS and SARS coronavirus outbreaks suggested that CP is safe and should confer clinical benefits, including faster viral clearance, particularly when administered early within the disease course1. The overwhelming majority of patients who get over COVID-19 illness develop circulating antibodies to varied SARS-CoV-2 proteins 2-3 weeks following infection, which are detectable by ELISA or other quantitative assays and sometimes correlate with the presence of neutralizing antibodies.

Donations can occur as frequently as weekly for several months before antibody titers begin decreasing. Allowed donation frequency varies between blood centers. Listed below are some sites for referral of potential donors:

• AABB
• FDA donate COVID-19 plasma
• Hyper immune globulin.
• National COVID-19 Convalescent plasma project

Cell and Gene Therapy:

Cells are the essential building blocks of all living things, and genes are often found deep within cells. Genes are small sections of DNA that carry genetic information and directions for creating proteins, which help build and maintain the body. Every person has around 20,000 genes and two copies of every of their genes—one from each parent. Small variations in genes end in differences in people’s appearance and, potentially, health. Genetic diseases happen when a critical piece or whole section of DNA is substituted, deleted or duplicated. These changes are called genetic mutations. Some serious genetic diseases caused by genetic mutations are often passed to future generations.

• AAV-based therapies
• CAR-T cell therapies
• CRISPR-based technologies
• Gene regulation therapies

Systems Analysis of Cancer:

Cancers remain the lead cause of disease-related, pediatric death in North America. The emerging field of complex systems has redefined cancer networks as a computational system with intractable algorithmic complexity. Herein, a tumor and its heterogeneous phenotypes are discussed as dynamical systems having multiple, strange attractors. Machine learning, network science and algorithmic information dynamics are discussed as current tools for cancer network reconstruction. Deep Learning architectures and computational fluid models are proposed for better forecasting gene expression patterns in cancer ecosystems. Cancer cell decision-making is investigated within the framework of complex systems and complexity theory.

• Stem cell reprogramming
• Boolean networks
• Fixed gene set enrichment analysis
• de novo Network construction and clustering
• Network based modeling

Stem Cell Niches:

Stem cells constitute a source of self-renewing cells with a potential to differentiate into distinct tissues. In the embryo, these cells supply the multiple different cell lineages necessary to generate functional organs. Adult tissues retain somatic stem cells with capabilities for specific tissue turnover and repair. Embryonic and adult stem cell research has shown that stem cell fates are controlled by their specialized microenvironment, referred to as the stem cell niche, via direct cell-cell interactions and the molecular signals emitting from the niche.

• Extracellular matrix and cell-cell interactions
• Stem cell niche dynamism
• Stem cell niche aging
• Malignant stem cell niches
• Molecular pathways associated with niche function

Cancer Stem Cell and Oncology:

Cancer Stem cells CSCs area unit rare timeless cells within a neoplasm which will hold the overall capability of a natural somatic cell with the flexibility of extremely proliferation and malignancy. They feed the neoplasm development associate degreed to border neoplasm and induce cancer in an organ. These extremely economical qualities of a cancer somatic cell area unit utilized in medication and therapeutic treatments in many diseases. Whereas medical specialty outline the study of nature, types, cause, interference and cure of cancer and neoplasm biology.

• Cancer somatic cell and neoplasm Biology
• Cancer genetics and metabolomics
• Radiation medical specialty
• Biomarker in cancer somatic cells
• Novel Cancer stem cell (CSC) regulative Mechanism

Bone Marrow Transplantation:

Bone marrow transplant (BMT) is a special therapy for patients with certain cancers or other diseases. A bone marrow transplant involves taking cells that are normally found in the bone marrow (stem cells), filtering those cells, and giving them back either to the donor (patient) or to another person.

• White blood cells to fight infections.
• Red blood cells to carry oxygen throughout the body.
• Platelets to control bleeding.

Retinal Pigment Epithelium:

The retinal pigment epithelium (RPE) is a single layer of post-mitotic cells, which functions both as a selective barrier to and a vegetative regulator of the overlying photoreceptor layer, thereby playing a key role in its maintenance. Through the expression and activity of specific proteins, it regulates the transport of nutrients and waste products to and from the retina, it contributes to outer segment renewal by ingesting and degrading the spent tips of photoreceptor outer segments, it protects the outer retina from excessive high-energy light and light-generated oxygen reactive species and maintains retinal homeostasis through the release of diffusible factors. The ageing characteristics of the RPE suggest that in addition to cell loss, pleomorphic changes and loss of intact melanin granules, significant metabolic changes occur resulting, at least in part, from the intracellular accumulation of lipofuscin. This pigment has been shown to be highly phototoxic and has been linked to several oxidative changes, some leading to cell death. While the etiology of age-related macular degeneration is complex and is as yet unresolved, it is likely that accelerated ageing-like changes in the RPE play a fundamental role in the development of this condition.

• Tran’s epithelial transport
• Retinoid transport and storage
• Phagocytosis and degradation of outer segments
• Age-related changes to the RPE
• Molecular damage and senescence
• Protection against light and free radicals
• Relationship between ageing and disease

Molecular Genetics:

Molecular genetics can be defined as “the use of recombinant DNA techniques to manipulate genetic information within and between plants, animals and microorganisms” to produce genetically modified organisms.

• Forward genetics
• Reverse genetics
• Genomic imprinting
• Mutagenesis
• Epigenetics

Stem Cell in Drug Discovery:

As explained Stem Cells area unit general cells that have the aptitude to totally differentiate in to different sort of cells and tissues that area unit the building blocks of body, that's completed by the tactic of regeneration and degeneration which can accustomed overcome the constraints of animal models in bound disorders. Similarly as in drug screening and drug discovery. Several methods area unit accustomed generate such sickness models exploitation either embryonic stem cells (ES cells) or patient-specific induced PSCs (iPSCs), that's making new era within the sector of sickness modeling and drug discovery.

• High thought place screening exploitation iPSCs
• Drug screening
• Upset modeling
• Sickness modeling exploitation iPS cells
• Vegetative cell toxicity testing

Cell Biology:

Cells consist of cytoplasm enclosed within a membrane, which also contains many biomolecules such as proteins and nucleic acid. The number of cells in plants and animals varies from species to species, it has been estimated that humans contain somewhere around 40 trillion (4×1013) cells. Enclosing the cell is that the cell envelope – generally consisting of a cell membrane covered by a cell wall which, for a few bacteria, could also be further covered by a third layer called a capsule.

• Eukaryotic cells
• Cytoskeleton
• Genetic material
• Growth and metabolism
• Prokaryotic cells

Report Overview

The global regenerative medicine market size was valued at USD 27.29 billion in 2021 and is expected to grow at a compound annual growth rate (CAGR) of 11.27% from 2022 to 2027. The emergence of gene therapy coupled with the developments in stem cell and tissue engineering are expected to fuel the market growth. In addition, increasing regulatory approvals for advanced therapy medicinal products have propelled the market growth. The ongoing COVID-19 pandemic created lucrative opportunities for the operating players owing to the urgent need for the development of new therapies against SARS-COV-2. Several initiatives are being implemented in the cell and gene therapy manufacturing industry, including the T-cell therapy space.

For instance, based on the previous research insights, Singapore-based Duke-NUS medical school’s emerging infectious diseases research program demonstrated the utility of these immunotherapies in treating patients with COVID-19 infection. The presence of several programs and continuous investments by government and private agencies to support R&D also accelerate the industry's progress. Like National Institutes of Health (NIH) supports the scientific research community through NIH Regenerative Medicine Program, NIH Stem Cell Libraries & Projects, NIH Stem Cell Unit, and others. Similarly, initiatives adopted by market players to raise finance for the R&D of regenerative medicine support the market progression.

In addition, companies are collaborating to strengthen their R&D capabilities to develop and commercialize innovative therapies to ensure their availability to their customers locally or worldwide. For instance, in July 2021, Pharming Group N.V. and Orchard Therapeutics collaborated for the development and commercialization of OTL-105, an investigational ex vivo autologous Hematopoietic Stem Cell (HSC) gene therapy for the treatment of Hereditary Angioedema (HAE).

Moreover, technological advancements in stem cell-based therapies have revolutionized the perspective of researchers toward regenerative medicine. Advances in stem cell therapy have accelerated the developments in regenerative medicine. For instance, haematogenic stem cells currently are being used to treat leukemia and blood disorders. Also, nanotechnology is a powerful tool for engineering stem cells and regenerative medicine. With the introduction of new technology, nanofabrication techniques can now allow researchers to develop nanofiber scaffolds.

Product Insights                            

The therapeutics segment accounted for the maximum revenue share of more than 56% in 2021 and is anticipated to continue its dominance throughout the forecast period. Among therapeutics vertical, primary cell-based therapies are the most developed therapeutics available due to their usage for different therapeutic indications and early adoption of these therapies in clinical application.

The stem cell &progenitor cell-based therapies segment is expected to register the fastest CAGR over the forecast years due to high investments in stem cell research coupled with redrafting in regulatory policies for their use in clinical applications. Allogenic stem cell-based therapies are estimated to account for the largest revenue share whereas autologous therapies are characterized with one of the fastest CAGRs.

Key vendors with specialized technology provide management, manufacturing, characterization, engineering, and quality control services along with other facilities for clinical trials and other research associated with the development of regenerative therapies. Hence, with a rise in R&D and clinical trials of regenerative medicines, the services segment is projected to witness rapid growth.

Report Coverage & Deliverables

PDF report & online dashboard will help you understand:

• Competitive benchmarking
• Historical data & forecasts
• Company revenue shares
• Regional opportunities
• Latest trends & dynamics

Therapeutic Category Insights

The application of regenerative therapies is maximum in the oncology segment, thus, it captured the largest revenue share of more than 31% revenue share in 2021. High cancer prevalence has resulted in the implementation of efficient cancer treatment options. Various government organizations, as well as private companies, have made high investments in cancer research and the development of regenerative & advanced cell therapies. Global efforts to reduce the cancer burden are also anticipated to drive the segment growth.

On the other hand, the presence of a strong product portfolio coupled with increasing incidences of musculoskeletal disorders is anticipated to boost the revenue of the musculoskeletal segment. The introduction of efficient regenerative solutions in form of stem cells and tissue engineering to restore the tissues and regain functional strength has led to the rapid development of the segment. Safe and potentially officious treatments are available in regenerative and cell-based therapies for the segment.

Furthermore, various novel approaches in developmental phases promote tissue engineering. This includes the use of biomaterials and drug delivery systems, which stimulate and control the immune system and influence cell replication. Increased complexity of the wound healing process with severe diseases, such as diabetes and HIV, has encouraged R&D approaches in the dermatology segment.

Regional Insight

North America dominated the global market in 2021 with a revenue share of more than 45%. This is attributed to the presence of a significant number of key players in the U.S. The availability of advanced technologies and the presence of research institutes that are involved in the development of novel therapeutics are attributive to the high number of clinical trials in this region.

Availability of funds as well as several initiatives by the government & private organizations contributes to the highest revenue flow from the U.S. For instance, the “2020: A New Vision” initiative of the U.S. Department of Health and Human Services recognizes regenerative medicine at the forefront of healthcare.

Asia Pacific is predicted to witness the fastest CAGR over the forecast period owing to the expansion of infrastructure and facilities to accelerate stem cell research in the emerging economies of the region. In Japan, the Ministry of Health, Labor and Welfare approved Regenerative Medicine law in April 2013, which propelled the clinical development of regenerative and cell-based therapies. Similarly, the Chinese government has approved several research activities related to human embryonic stem cells that have encouraged researchers to explore the clinical potential of these cells.